Point-of-Care Platelet Function Monitoring: Implications for Patients With Platelet Inhibitors in Cardiac Surgery
نویسندگان
چکیده
Although most physicians are comfortable managing the limited anticoagulant effect of aspirin, recent administration potent P2Y12 receptor inhibitors in patients undergoing cardiac surgery remains a dilemma. Guidelines recommend discontinuation 5- to- 7 days before to reduce risk postoperative hemorrhage. Such strategy might not be feasible urgent surgery, due ongoing myocardial ischemia or at high for thromboembolic events. Recently, different point-of-care devices assess functional platelet quality have become available clinical use. The aim this narrative review was evaluate implications and potential benefits function monitoring guiding perioperative management therapeutic options treated with antiplatelets, including aspirin inhibitors, surgery. No objective superiority one device over another found large meta-analysis. Their accuracy reliability generally period. In particular, preoperative testing has been used contribution bleeding after However, predictive values hemorrhage transfusion requirements low, there is significant variability between within these tests. Further, optimize waiting period cessation dual antiplatelet therapy Furthermore, studies assessing their value decisions scarce. A general liberal use yet recommended. IN PATIENTS PRESENTING acute coronary syndrome, first treatment occlusive artery disease (CAD) usually involves percutaneous intervention stenting. 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Polymorphisms cytochrome P450 (CYP) system relevantly influence efficacy clopidogrel. genetic polymorphisms do completely explain interindividual pharmacodynamic responses, affect outcome.31Sousa-Uva Scholar,34Parodi Marcucci Valenti al.High residual reactivity loading among PCI.JAMA. 306: 1215-1223Crossref (333) ScholarTable 1Comparison Pharmacological Properties Receptor InhibitorsClopidogrelPrasugrelTicagrelorCangrelorPlatelet inhibitionModerateStrongStrongStrongBioavailability30%-50% (po)80% (po)36% (po)100% (iv)Pharmacological reversibilityIrreversibleIrreversibleReversibleReversibleOnset action2-6 h30 min30 min2 minDuration effect5-10 d7-10 d3-5 d1-2 hAbbreviations: iv, intravenous; po, peroral. Open table new tab Abbreviations: Prasugrel ticagrelor third-generation rapid consistent anti-ischemic effect, caused stronger inhibition clopidogrel.15Drews Scholar,28Mazzeffi Scholar,31Sousa-Uva Therefore, currently preferred choice presenting Genetic variants CYP2C19 platelet-inhibiting prasugrel,35Jin Kim MH Guo LZ al.Pharmacodynamic study non-ST-elevation syndrome (PRAISE-GENE trial).Int 305: 11-17Abstract interactions CYP3AA described, suppressed metabolism consecutively prolonged half-life ticagrelor.36Azran Interaction CYP3A4 inhibitor: Importance recovery 3221-3222Abstract According expert opinions, does seem confer events.31Sousa-Uva For ticagrelor, postponing 2 3 significantly reduced analyses.16Vuilliomenet Scholar,37Holm Biancari Khodabandeh al.Bleeding grafting.Ann 107: 1690-1698Abstract thrombosis, bridging novel cangrelor an option.38Angiolillo DJ Firstenberg MS Price al.Bridging trial.JAMA. 307: 265-274Crossref (314) Scholar,39Williams Henderson Reformato VS al.Hemostasis emergency loading.J 168-174Abstract (4) Cangrelor very short 3- 6 minutes, normal returns hour, allowing discontinuation.38Angiolillo Alternatively, individualized intervals increasingly patient-specific late take into account emergency, status, type anatomic localization implanted implantatio
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ژورنال
عنوان ژورنال: Journal of Cardiothoracic and Vascular Anesthesia
سال: 2021
ISSN: ['1053-0770', '1532-8422']
DOI: https://doi.org/10.1053/j.jvca.2020.07.050